INTEGRIS Bennett Fertility

Phone

Address

3433 NW 56th
Bldg. B, Suite 200
Oklahoma City, OK 73112

Metformin

By reducing blood levels of insulin, metformin (Glucophage), a medication commonly prescribed for diabetes, has been shown to induce ovulation in patients with polycystic ovarian syndrome (PCOS). Insulin, directly or indirectly, stimulates ovarian production of male hormones, which interf ere with ovulation. Reduction of insulin results in decreased male hormone production and either ovulation or reduction in the need for high doses of clomiphene. Metformin is given at doses of 500 to 2500 mg daily, either alone or in conjunction with clomiphene or injectable gonadotropins. To reduce side effects, metformin dose should be increased gradually over several weeks.

Indications

Patients with chronic anovulation, especially patients with elevated male hormones (PCOS), may benefit most from metformin.

Contraindications and adverse effects

Nausea and diarrhea are very common, usually decreasing with longer use. A serious complication called lactic acidosis may occur in patient s with damaged kidneys or patients suffering from vomiting from unrelatedcauses (e.g. infection, pregnancy). In patients who are not diabetic, metformin rarely results in low blood sugar. Modest weight loss may occur with metformin, though it is not a weight-loss medication.

METFORMIN IS NOT APPROVED AT PRESENT BY THE FDA FOR OVULATION INDUCTION. PLEASE DISCUSS ITS USE WITH YOUR FERTILITY SPECIALIST.